You can use DjVu Solo or similar DjVu utility that allows users to transcode various picture image file formats (for example TIFF or JPEG) to DjVu images. The resulting .djvu file will be typically much smaller in size, with each picture on separate page.
Convert Aldus Tagged Image File Format (TIFF) bitmap image to DjVu image file.
We found one software available in the database for this conversion.
Microsoft Windows software - convert tiff to djvu on Windows
A program for making DJVU images
Convert from tiff file format
The table with program actions contains information about what each program is capable of doing with their files. This may be a good pointer for further searches for certain file conversions and help you find the converter you are looking for if our search result is insufficient for you. However, it is far from perfect and may sometimes show results which are not really usable because of the nature of the software handles the files. So a conversion that appears as possible, just because of matched actions, may in fact not be possible.