We have found one software suitable in our database for this conversion.
You can use DjVu Solo or similar DjVu utility that allows users to transform various picture image file formats (for example TIFF or JPEG) to DjVu images, i.e. perform tiff to djvu conversion. The resulting .djvu file will be typically much smaller in size, with each picture on separate page.
Updated: November 18, 2022
TIFF
Files with tiff extension are bitmap images in the Tagged Image File Format. Usually having the extension TIF, it's one of the more common graphics file types.
DJVU
A djvu file extension is used for a special image and document file format called DjVu. Typically used for image documents because it can achieve much lower file sizes, compared to other image formats with text, such as JPEG.